Dr Rutledge talks about the role of urate, xanthine oxidase and the effects of allopurinol in vascular oxidative stress. Oxidative stress plays an important role in the progression of vascular endothelial dysfunction. The two major systems generating vascular oxidative stress are the NADPH oxidase and the xanthine oxidase pathways. Allopurinol, a xanthine oxidase inhibitor, has been in clinical use for over 40 years in the treatment of chronic gout. Allopurinol has also been shown to improve endothelial dysfunction, reduce oxidative stress burden and improve myocardial efficiency by reducing oxygen consumption in smaller mechanistic studies involving various cohorts at risk of cardiovascular events. This article aims to explain the role of xanthine oxidase in vascular oxidative stress and to explore the mechanisms by which allopurinol is thought to improve vascular and myocardial indices. The Mini-Gastric BypassCall Dr. Rutledge 702-714-0011 or Email: DrR@clos.net, Web: mgb.fm Amazing New Findings! New studies to be presented at the Paris Meeting for the International Federation for Surgery of Obesity and Metabolic Diseases show that in a controlled prospective 5 year trial the MGB is better than the RNY gastric bypass.
Orignal From: Dr Rutledge talks about Uric Acid and Death
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